One neuroprotective lignanamide from Solanum Septemlobum Thunb
The whole plant of <i>Solanum Septemlobum</i> Thunb., called Shu Yangquan in traditional Chinese medicine, has the traditional function of clearing away heat and toxic material. Chemical investigation on the ethanol extract of <i>S. Septemlobum</i> afforded a new lignanamide (<b>1</b>) and a known compound caffeic acid ethyl ester (<b>2</b>). Compound <b>1</b> displayed moderate antineuroinflammatory effects (IC<sub>50</sub> values of 25.3 μM) compared with minocycline (IC<sub>50</sub> value of 12.1 μM) against NO production on LPS-treated BV2 cells.
Authors
- Jiena Wang
- Hongwei Liu (ORCID: https://orcid.org/0000-0002-8200-8801)
- Hui Zhang (ORCID: https://orcid.org/0000-0001-7770-2471)
- Yang-Cheng Liu
Institutions
- Liaoning University (CN)
- Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Liaoning Cancer Hospital & Institute (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-03-11
- DOI
- https://doi.org/10.1080/14786419.2025.2477209
- Primary Topic
- Traditional and Medicinal Uses of Annonaceae
- Type
- article
- Field-Weighted Citation Impact
- 0.00