Epidemiology of first-time major lower extremity amputations– A Danish Nationwide cohort study from 2010 to 2021

We observed a decreasing incidence of first-time MLEA in Denmark and a shift towards increased use of transfemoral amputations as initial MLEA level. Investigation of the comorbidity profile of MLEA patients revealed some time trend changes during the study period, but with limited clinical relevance. Hence, the observed prominent shift towards a more proximal first time amputation level in Denmark did not seem to be associated with an altered comorbidity profile of these patients. Whether the change in surgical strategy is to the benefit of the patients should be investigated further.