Aberrant DNA methylation of genes regulating CD4+ T cell HIV‐1 reservoir in women with HIV
Study involved 427 women with HIV. Identified 245 aberrant DNA methylation sites and 85 methylation regions in CD4+ T cells linked to the HIV-1 reservoir. Highlighted genes are involved in viral replication, immune defence, and host genome integration. Findings suggest potential molecular targets for eradication strategies.
Authors
- Jack DeHovitz (ORCID: https://orcid.org/0000-0001-7307-0614)
- Bradley E. Aouizerat (ORCID: https://orcid.org/0000-0002-6047-9397)
- Dana B. Hancock (ORCID: https://orcid.org/0000-0003-2240-3604)
- Cecile Delille Lahiri (ORCID: https://orcid.org/0000-0002-5605-8266)
- Amir Valizadeh (ORCID: https://orcid.org/0000-0001-5983-8527)
- Bryan C. Quach (ORCID: https://orcid.org/0000-0002-1094-3104)
- Kesava Asam (ORCID: https://orcid.org/0000-0002-6247-9905)
- Mark H. Kuniholm (ORCID: https://orcid.org/0000-0002-0173-9806)
- Nancie M. Archin (ORCID: https://orcid.org/0000-0002-7938-0389)
- Claudia Martinez (ORCID: https://orcid.org/0000-0002-2489-6193)
- Grier P. Page (ORCID: https://orcid.org/0000-0003-2582-3786)
- Elizabeth T. Golub (ORCID: https://orcid.org/0000-0001-5860-4913)
- Ke Xu (ORCID: https://orcid.org/0000-0002-6472-7052)
- Deborah J. Konkle‐Parker (ORCID: https://orcid.org/0000-0002-3319-8442)
- Vincent C. Marconi (ORCID: https://orcid.org/0000-0001-8409-4689)
- Seble Kassaye (ORCID: https://orcid.org/0000-0002-7527-7384)
- Mardge H. Cohen (ORCID: https://orcid.org/0000-0002-1351-9624)
- Eric O. Johnson (ORCID: https://orcid.org/0000-0002-8870-1949)
- Xinyu Zhang (ORCID: https://orcid.org/0000-0002-0809-3817)
- Phyllis C. Tien
Institutions
- Albany State University (US)
- University of North Carolina at Chapel Hill (US)
- Johns Hopkins University (US)
- University of Miami (US)
- Emory University (US)
- RTI International (US)
- University of California, San Francisco (US)
- SUNY Downstate Health Sciences University (US)
- Georgetown University (US)
- University of Mississippi Medical Center (US)
- Yale University (US)
- University at Albany, State University of New York (US)
- VA Connecticut Healthcare System (US)
- Georgia Department of Public Health (US)
- Atlanta VA Medical Center (US)
- Cook County Health and Hospitals System (US)
- New York University (US)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/ctm2.70267
- Citations
- 1
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.04
Funders
- National Institute on Drug Abuse