The Effect of Twelve Weeks of Resistance Training and Creatine Hydrochloride Supplementation on Blood Oxygen Levels and Fatigue in Cognitive Activities of Middle-Aged Men

Background and Objectives Cognitive performance is influenced by health-related factors such as physical fitness and nutrition, as well as cognitive exercises such as brain games. The aim of the present study was to investigate the effect of twelve weeks of resistance training and creatine hydrochloride supplementation on blood oxygen levels and fatigue in cognitive activities of middle-aged men. Subjects and Methods In the present quasi-experimental study, 36 middle-aged men were randomly divided into three groups: resistance training + supplement (n = 12), resistance training + placebo (n = 12), and control group (n = 12). Resistance training was completed for 12 weeks with a frequency of four sessions per week and an intensity of 70 to 85% of one repetition maximum. Also, in the supplement group, creatine hydrochloride was consumed at a rate of three grams per day. Fatigue and arterial oxygen were measured in two stages: pre-test and post-test, before and after the Mafia game. Results A significant decrease in fatigue was observed in the resistance training + supplement groups (P < 0.001) and resistance training + placebo (P < 0.001) compared to the control group. The results of blood oxygen levels between the groups in the first and second stages did not show a significant difference (P > 0.05). Conclusion A period of resistance training significantly improved fatigue without affecting arterial oxygen levels, but supplementation had no significant effect on fatigue and arterial oxygen.