p53 inhibits OTUD5 transcription to promote GPX4 degradation and induce ferroptosis in gastric cancer
OTUD5 mediates GPX4 deubiquitination to regulate its stability. Deletion of OTUD5 promotes ferroptosis and inhibits tumor growth. Wild type p53 inhibits OTUD5 transcription, thereby promoting GPX4 degradation and inhibiting the development of gastric cancer. OTUD5, GPX4 expression and p53 activity are highly correlated and correlates with clinical progression in STAD.
Authors
- Yao Lu (ORCID: https://orcid.org/0000-0001-8511-3642)
- Zhenxiang Wang (ORCID: https://orcid.org/0000-0002-2518-1528)
- Lei Lv (ORCID: https://orcid.org/0000-0003-4820-3125)
- Yuefan Zhou (ORCID: https://orcid.org/0009-0000-4531-6373)
- Xinxing Li (ORCID: https://orcid.org/0000-0002-4773-1615)
- Tongguan Tian (ORCID: https://orcid.org/0000-0002-2030-762X)
- Ziyi Cui
- Junjing Zhang (ORCID: https://orcid.org/0000-0002-1274-1098)
- Kai Xu (ORCID: https://orcid.org/0000-0002-2082-4643)
- Xia Li (ORCID: https://orcid.org/0000-0003-2679-9917)
- Yan Zhang (ORCID: https://orcid.org/0000-0001-9795-0827)
- Yixin Xu (ORCID: https://orcid.org/0000-0003-2164-1483)
- Xinyu Zhao (ORCID: https://orcid.org/0000-0002-5128-4424)
- Yu Du (ORCID: https://orcid.org/0000-0002-9654-164X)
- Hongchen Li (ORCID: https://orcid.org/0009-0006-2317-8305)
- Yanping Xu
Institutions
- Tongji University (CN)
- Fudan University (CN)
- Tongji Hospital (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/ctm2.70271
- Citations
- 14
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 21.26
Funders
- National Natural Science Foundation of China
- Shanghai Rising-Star Program
- National Key Research and Development Program of China