4CPS-185 Evaluate the impact of a pharmaceutical intervention to improve the adequacy of antibiotic consumption

<h3>Background and Importance</h3> Spain is characterised by a high use of antibiotics (ATB) and, in parallel, high rates of resistance, whose consequences in terms of health are characterised by therapeutic failures and associated morbidity and mortality. Since 2014, the National Plan against Antibiotic Resistance (PRAN) has been in place and most of the Autonomous Communities have implemented an Antibiotic Optimisation Programme (PROA). <h3>Aim and Objectives</h3> Our objective is to reduce antibiotic consumption through a pharmaceutical intervention, improving the adequacy of antibiotic treatment. <h3>Material and Methods</h3> Prospective Intervention Study in a Health Area (36 primary health care centres, with 673 general practitioners (GPs) and 80 paediatricians, serving 677,782 inhabitants, distributed in urban and rural areas). Study period: The intervention was carried out in 2022–2023. The intervention consisted of: Training sessions, Dissemination to all GPs, paediatrics and emergency departments of algorithms for the most prevalent infectious processes in Primary Care as a prescription aid tool: Pharyngotonsillitis in adults; Acute community-acquired pneumonia; Acute bronchitis; COPD exacerbation; Odontogenic infections; Symptomatic UTI in institutionalised elderly; Cystitis in women; Cystitis in pregnancy; UTI in men; Pneumonia in institutionalised elderly. The outcome variable was the defined daily doses per 1000 inhabitants per day (DDD) (Therapeutic group J01). <h3>Results</h3> The evolution of antibiotic consumption rates in recent years (DHD): Urban Area: 2018 (11,96), 2019 (11,56), 2020 (8,72), 2021 (8,78), 2022 (10,71), 2023 (10,76). Rural Area: 2018 (14,83), 2019 (14,91), 2020 (11,31), 2021 (11,34), 2022 (13,95), 2023 (14,39). For the evaluation, the period 2018–2023 has been studied to ascertain pre-pandemic antibiotic consumption rates. <h3>Conclusion and Relevance</h3> 1. Algorithms, as prescription support tools, provide quick access, as well as basic information on the treatment of the most frequent infectious processes. The use of these algorithms facilitates compliance with the objectives of the PROA (optimising the use of antibiotics, minimising adverse effects, improving bacterial resistance and ensuring cost-effective treatment). 2. The intervention has not yet reached pre-pandemic AB rates, although it is necessary to continue working to reduce the consumption of antibiotics, improving their appropriateness. <h3>References and/or Acknowledgements</h3> <h3>Conflict of Interest</h3> No conflict of interest