5PSQ-141 Impact of cabotegarvir and rilpivirine long-acting in quality of life of subjects in a real-world setting: preliminary data

<h3>Background and Importance</h3> Long-acting (LA) injectable therapy with cabotegravir (CAB) and rilpivirine (RPV) may improve quality of life. General health was assessed in clinical trials about LA CAB+RPV using the 12-Item Short Form Health Survey (SF-12) questionnaire, that includes norm-based physical and mental component scores (PCS and MCS) ranging from 0 to 100 points, with higher scores indicating better health.¹ <h3>Aim and Objectives</h3> To describe the quality of life, according to the SF-12 questionnaire, of patients in treatment with LA CAB+RPV in a real-world setting. <h3>Material and Methods</h3> We conducted a multicentre, non-controlled, retrospective and prospective study (relativity cohort) in HIV patients on treatment with LA CAB+RPV. Patients could answer the SF-12 questionnaire between 9–14 months of treatment via electronic devices using a QR code provided. The data were collected on the RedCap platform for subsequent analysis. <h3>Results</h3> The study included 205 patients from 13 hospitals in Spain. Median age of patients is 46.0 (38.2, 55.4) years and 88.7% males. The current follow-up duration is 13.1 (11.0, 15.1) months. At the time of answering the questionnaire patients had a median score in SF-12 of 55.5 (52.4, 57.2) in PCS and 53.1 (44.7, 57.8) in MCS. 189 (92.2%) of the patients considered that at the time of the study their health status was good, very good or excellent. 178 (86.8%) patients had no limitations for moderate activities, 187 (91.2%) patients answered that they continued with their daily activities and 174 (84.9%) patients that they had no pain that hindered their usual work. 168 (82.0%) patients responded that their emotional state of health had not prevented them from carrying out their daily activities as carefully as usual(MOU1). 155 (75.6%) patients had no physical or emotional difficulties in continuing their social activities. <h3>Conclusion and Relevance</h3> The PCS and MCS scores are similar to those described in the healthy US population (mean of 50). Our data suggest that patients with LA CAB+RPV have a good state of physical and mental health. Longer follow-up in more patients is needed to obtain more consistent data. <h3>References and/or Acknowledgements</h3> <i>AIDS and Behaviour</i>, <b>24</b>(12), 3533–3544. https://doi.org/10.1007/s10461-020-02929-8 <h3>Conflict of Interest</h3> No conflict of interest