4CPS-173 Analysis of the evolution of nutritional status using the C-reactive protein/prealbumin ratio in critically ill patients with parenteral nutrition

<h3>Background and Importance</h3> Disease-related malnutrition is characterised by the presence of an acute or chronic inflammatory response, there is a need to adapt clinical data to new specific markers that assess both nutritional and inflammatory changes. The C-reactive protein (CRP)/prealbumin ratio is useful for assessing nutritional changes associated with the inflammatory environment. <h3>Aim and Objectives</h3> To analyse the evolution of nutritional status from the biochemical parameter CRP/in critically ill patients with parenteral nutrition (PN). <h3>Material and Methods</h3> Descriptive observational restrospective study in a tertiary level hospital from January to July 2024. The evolution of the CRP/prealbumin ratio was analysed at the beginning, fourth and seventh day of PN. Anthropometric data on sex, age, height and BMI; clinical data on pathology, hospitalisation unit, duration of PN; and biochemical data on CRP and prealbumin were collected from the patients‘ electronic medical records. <h3>Results</h3> A sample of 38 patients with a median age of 71 (20) years, mostly male [65.8% (25)], with a median weight of 72 (20) kg, height 169 (8) cm and BMI=26.5 (5.8) kg/m2 was analysed. The pathologies of the patients were 42.0% (16) gastrointestinal disease, 29.0% (11) septic shock, 23.7% (9) neoplasia, 5.3% (2) polytrauma. At the start of PN, 85.0% (32) of patients were admitted to the surgical intensive care unit and 16.0% (6) to the medical intensive care unit. Regarding CRP levels, a median of 138.45 (8.5) mg/L was obtained at baseline, 106.1 (113.9) mg/L at day 4 and 62.3 (135.6) mg/L at day 7. Median pre-albumin levels at day 1 were 9.7 (7.3) mg/dL, at day 4, 13 (6.9) mg/dL and at day 7, 17.4 (5) mg/dL. The CRP/prealbumin ratio was calculated, with a median of 1.3 (2.3) on day 1, 1.1 (1.3) on day 4, and 0.4 (5) on day 7. <h3>Conclusion and Relevance</h3> A decrease in the CRP/prealbumin ratio was observed as patients continued with PN, showing an improvement in nutritional and inflammatory status, and could therefore be considered as a complementary marker in patient assessment. <h3>References and/or Acknowledgements</h3> <h3>Conflict of Interest</h3> No conflict of interest