5PSQ-001 Potential and clinically manifested drug-drug interactions in patients admitted to the hospital: a cross-sectional study

<h3>Background and Importance</h3> Drug-drug interactions (DDIs) are increasingly common in ageing populations. Although many studies address potential DDIs, few explore clinically manifested DDIs. <h3>Aim and Objectives</h3> To provide information on the prevalence and characteristics of potential and clinically manifested DDIs in patients admitted to the hospital. <h3>Material and Methods</h3> This study included patients from our previous study¹ with a minimum of two medications in their medication history. Data were obtained from electronic health records. Potential DDIs were identified using Lexicomp (via UpToDate), Micromedex and Stockley’s drug interactions database. Potential DDIs were defined as those detected by at least one DDI database with moderate or greater severity. Clinically manifested DDIs were defined as those linked to clinically adjudicated adverse drug events. <h3>Results</h3> The study involved 968 patients with a mean age of 73 and a mean of seven medications. Potential DDIs were identified in 90% (95% CI: 88–92) of patients. Most were categorised as pharmacodynamic and moderate in severity. Diuretics, antithrombotic agents, and drugs used in diabetes represented medication classes most frequently involved in potential DDIs. Clinically manifested DDIs were observed in 6% (95% CI: 5–8) of patients, primarily involving gastrointestinal haemorrhage, with antithrombotic agents being the most common culprits. <h3>Conclusion and Relevance</h3> A high prevalence of potential DDIs was found among acutely admitted hospital patients, though clinically manifested DDIs were less common. Compared to previous research, the rate of DDIs was significantly higher, underscoring the issue’s growing importance. The discrepancy between potential and clinically manifested DDIs points to the need for targeted alert systems to prevent alert fatigue. Drug interaction databases showed a DDIs prevalence twice as high as the international consensus list of potentially clinically significant DDIs in older people.^{2 3} <h3>References and/or Acknowledgements</h3> Očovská Z, MaŘíková M, Kočí J, Vlček J. Drug related hospital admissions via the department of emergency medicine: a cross-sectional study from the czech republic. <i>Front Pharmacol</i>. 2022;<b>13</b>:899151. doi: 10.3389/fphar.2022.899151 Očovská Z, MaŘíková M, Vlček J. Potentially clinically significant drug-drug interactions in older patients admitted to the hospital: a cross-sectional study. <i>Front Pharmacol</i>. 2023;<b>14</b>:1088900. doi: 10.3389/fphar.2023.1088900 Anrys P, <i>et al</i>. An international consensus list of potentially clinically significant drug-drug interactions in older people. <i>J Am Med Dir Assoc</i>. 2021;<b>22</b>(10):2121–2133.e24. doi:10.1016/j.jamda.2021.03.019 <h3>Conflict of Interest</h3> No conflict of interest