5PSQ-113 Vitamin D prescription in complex chronic patients and pharmaceutical interventions to tratment optimisation

<h3>Background and Importance</h3> Some studies have shown an unjustified increase in vitamin D supplementation, despite potential risks of adverse events. Current guidelines advise evaluating the benefit-risk ratio and considering deprescribing when needed. <h3>Aim and Objectives</h3> Evaluate the vitamin D prescriptions in complex chronic patients (CCP) and assess the acceptance of pharmaceutical interventions carried out in primary health care to optimise treatment. <h3>Material and Methods</h3> An observational and prospective study was performed in a tertiary hospital from February to May 2024. Pharmacotherapeutic reconciliation was carried out in CCP, who was admitted to the hospital in February. Those with a prescription for calcifediol and/or cholecalciferol in their electronic prescription were selected. Pharmaceutical interventions were conducted for the primary care team in those patients meeting the Less-Chron deprescribing criteria and those lacking analytical follow-up in the last year, to evaluate the need to continue the supplementation. The acceptance of these interventions was evaluated in May. Sociodemographics and analytical data were collected from clinical records. <h3>Results</h3> Medication reconciliation was performed on 284 PCC and 94 (33%) were included with a prescription for vitamin D (57% women, 80±11 years). The 36% (34) lacked prior vitamin D measurement. Of those measured, 13% (12) had &gt;20 ng/ml, 19% (18) had 10–20 ng/ml, and 32% (30) had &lt;10 ng/ml. A total of 41 pharmaceutical interventions were conducted: 83% (34) due to lack of analytical follow-up and 17% (7) based on meeting the Less-Crohn deprescribing criteria. The 20% (8) of the interventions were not evaluable due to loss of patient follow-up. The acceptance was evaluated in 29 patients in the follow-up group and 4 in the Less-Crohn. The acceptance of the interventions was 34% (10) and 75% (3), respectively. <h3>Conclusion and Relevance</h3> This study reveals a lack of assessment of vitamin D levels prior to the initiation of supplementation, as well as a lack of follow-up during treatment. The implementation of pharmaceutical interventions for patients with vitamin D prescriptions demonstrated a significant opportunity to optimise pharmacotherapy in complex chronic patients. The ongoing evaluation of patient follow-up is essential to enhance the effectiveness of these interventions, ensure appropriate management of chronic conditions, and avoid overprescription in unnecessary situations. <h3>References and/or Acknowledgements</h3> <h3>Conflict of Interest</h3> No conflict of interest