5PSQ-067 Analysis of the HIV (human immunodeficiency virus) post-exposure prophylaxis (PEP) programme in a tertiary hospital

<h3>Background and Importance</h3> Post-exposure prophylaxis (PEP) to HIV is used to prevent transmission of the virus after a risky exposure and can be classified as occupational (OPEP) or non-occupational (NOPEP). To implement these PEP programmes, a protocol has been in effect since 2016. <h3>Aim and Objectives</h3> Analyse whether the clinical practice adapts to the protocol developed in a hospital and detect improvement points. Moreover, to perform a descriptive analysis of the population served at the centre. <h3>Material and Methods</h3> The study follows a retrospective and descriptive analysis of patients treated in the PEP programme from 2016 to 2023 who were treated after HIV exposure according to the protocol. It includes description of clinical visits, serologies and dispensations of the medication. <h3>Results</h3> A total of 92 patients were analysed, 65 men, median age 30 years (16–63). The established protocol was followed in 80 (87%) patients. The time to start PEP was less than 24 hours in 61/92 patients. In 70 patients the exposure was NOPEP type while 22 patients follow OPEP. In the NOPEP group, the sexual route occurred in 69/70 patients, and in the OPEP group the percutaneous route through a hollow needle was the most abundant. Also, 81/92 patients completed the treatment. Statistics show that 87% of the patients attended the specialist clinical consultation and 72% attended the monthly follow-up. Initial serology was performed in 97% of patients and control serology in 64%. All results were negative except one case. Losses to follow-up are mainly due to transfers to the reference healthcare area or unknown reasons. One patient stopped treatment after reevaluation. Only seven patients were included in PreP (pre-exposure prophylaxis programme). <h3>Conclusion and Relevance</h3> The circuit of action is well defined in the protocol. The initiation of PEP and baseline serologies are carried out adequately, but the follow-up through clinical consultations and serologies after 1 month is a point that can be improved. Furthermore, the population studied agrees in characteristics with those of the reference population. This study shows the importance of implementing standardised protocols in the clinical approach. This implies its periodic review. Additionally, this protocol allows passive recruitment in PreP programmes. <h3>References and/or Acknowledgements</h3> <h3>Conflict of Interest</h3> No conflict of interest