6ER-024 Adherence to inhaled treatment in patients with severe uncontrolled asthma on treatment with biological therapy

<h3>Background and Importance</h3> Medication adherence is essential in the treatment of patients with severe uncontrolled asthma. The improvement in symptoms may vary depending on the type of biological therapy used, which in turn may influence the administration and adherence to inhaled therapy in these patients. <h3>Aim and Objectives</h3> The objective of this study was to describe and evaluate treatment adherence to bronchodilators and inhaled corticosteroids in patients with any biological therapy for severe uncontrolled asthma. <h3>Material and Methods</h3> A retrospective and descriptive study of adherence to inhaled treatment was carried out in patients diagnosed with severe uncontrolled asthma who were being treated with biological therapy. Data collection was carried out from May 2023 to May 2024. Optimal adherence was considered above 80% according to the dispensation record. <h3>Results</h3> The study included 150 patients with a diagnosis of severe uncontrolled asthma who were receiving inhaled treatment and biological therapy. Characteristics of the patients at baseline are shown in table 1. 76% of patients had optimal adherence to treatment with bronchodilators and inhaled corticosteroids. Regarding adherence to inhaled treatment and biological therapy: patients treated with Dupilumab had an adherence to inhaled treatment of 81,8%, with benralizumab and omalizumab of 78,3%, with reslizumab of 75,3% and with mepolizumab of 74,5%. No statistically significant differences were found between the choice of biological therapy and adherence to inhaled treatment. <h3>Conclusion and Relevance</h3> Three out of four patients treated with biological therapy had optimal adherence to inhaled treatment despite clinical improvement and a decrease in exacerbations throughout the follow-up with biological therapy. The choice of biological therapy did not affect adherence to inhaled therapy. <h3>References and/or Acknowledgements</h3> <h3>Conflict of Interest</h3> No conflict of interest