4CPS-105 Evaluation of adherence and viral load according to the antiretroviral treatment regimen in patients with HIV

<h3>Background and Importance</h3> Optimal adherence is necessary for HIV viral suppression. The tolerance and the complexity of the treatment are factors related to non-adherence. <h3>Aim and Objectives</h3> Determine if there are differences in adherence rate and viral suppression according to antiretroviral (ART) regimen. <h3>Material and Methods</h3> Retrospective observational multidisciplinary study including HIV adult patients, on ART treatment in November 2023, at least for 3 months. Adherence to ART was calculated assessing the medication possession rate (MPR) in the previous 12 months. The nearest viral load to inclusion date are obtained, considering viral suppression as HIV RNA&lt; 50 copies/mL ART regimen was classified as follow: protease inhibitor (PI) based, integrase inhibitor (INSTI) based, non-nucleoside reverse transcriptase inhibitor (NNRTI) based, INSTI plus NNRTI based and all other regimens. Means (or medians) and standard deviations (or interquartile ranges) were used for continuous variables. Frequencies and percentages for categorical variables in the descriptive analysis too. Statistical calculations were performed using SAS System v9.4 software. Statistical significance was assumed when p&lt;0.05. <h3>Results</h3> 574 patients were selected. The mean patient age was 54.5 years old (SD 11.0), 71.4% of patients were male. Overall, 531 (92.5%) patients were virally suppressed (92.9% if we excluded naïve patient with less than 48 week in treatment). Median CD4+ count was 659.0 (IQR 465–872) and the overall mean adherence was 95.7% (SD 9.6). INSTI- based treatment was the most commonly prescribed regimen in 267 (46.5%) cases, NNRTI in 126 (22%), INSTI/NNRTI in 92 (16%), PI in 49 (8.5%) and all other-based regimens in 40 (7%). The mean adherence according to the type of treatment was INSTI 95.4% MPR (SD 10.5); NNRTI 96.0% (SD 7.4); INSTI/NNRTI 96.8% (SD 8.2); PI 95.3% (SD10.4); all other 93.7% (SD 10.7). There were no differences between the treatment groups in relation to adherence (p= 0.235). Neither in terms of age, sex or viral load. <h3>Conclusion and Relevance</h3> In our cohort of study, we did not detect any significant differences in adherence nor viral suppression according to the type of treatment. <h3>References and/or Acknowledgements</h3> <h3>Conflict of Interest</h3> No conflict of interest