6ER-019 Colchicine: hospital-wide evaluation and benefits of a video course

<h3>Background and Importance</h3> The 2024 update of ‘Never Events’ by the ANSM put Colchicine on the front stage. Colchicine is widely used and its good prescription is a necessity, especially for the elderly. <h3>Aim and Objectives</h3> Through an educational video and a survey, we aimed to inform HP about colchicine to prevent mistakes in prescription. <h3>Material and Methods</h3> Three pharmacists created a survey on colchicine about: indications, adverse events and toxicity, usual dosing, medical interactions, pharmacokinetic, patient advice, and improvement ideas. The form was shared via paper, a QR code, or by email to the HP in our hospital. <h3>Results</h3> We made an educational video highlighting the critical points in the knowledge of colchicine. 54 forms were collected. 50% were from medical doctors (mostly geriatrics, nephrology and emergency department), 25.9% nurses, 18.5% pharmacists and 5.6% pharmacy technicians. Critical points: the rate of correct answers for the true item ‘0.5mg per day initially for elderly patients’ were of 74%. It was of 83% for the item about the adequate dosing in patients with renal failure, of 88% for the inappropriate drug associating colchicine and opium which hides the first signs of overdosing, and of 85% for the true risk of medical interactions with some antibiotics (macrolids). Most errors concerned: the lack of knowledge on colchicine’s cardiac toxicity (70%), the ignorance of medical interactions with cholesterol regulating drugs (statins) and anti-infectious drugs of imidazoles type (63%). Lastly, the inadequate use of colchicine chronically in the prevention of gout attacks was deemed true by 31%.The most frequent cause of overdosing was renal failure (57%), intentional overdosing or hepatic failure (experienced by 28% HP). As for the most rated idea for risk management: 63% thought that the production of 0.5mg pills, fit for the elderly and patients with renal failure, would be an improvement. The video assessing the issues of the survey is shared through the hospital’s document management system. <h3>Conclusion and Relevance</h3> The survey showed an overall good knowledge about colchicine. We aim for an improvement, especially for nurses and pharmacy technicians who can give alert in case of a prescription mistake. We will conduct an analysis of the prescriptions before and after the video to evaluate the impact. <h3>References and/or Acknowledgements</h3> <h3>Conflict of Interest</h3> No conflict of interest