4CPS-071 What gets measured, gets managed! Analysis of antimicrobial stewardship process quality indicators at a university hospital

<h3>Background and Importance</h3> Antibiotic resistance is a serious global challenge and responsible for over 1.27 million deaths in 2019. <h3>Aim and Objectives</h3> Antimicrobial stewardship programmes (AMS) promote the rational use of antimicrobials (AM) to reduce resistance, reduce consumption and improve patient care. Monitoring the quality of antibiotic prescribing using process quality indicators (QIs) is essential for the success of AMS. QIs need to be validated in the setting before routine use. This study validated 17 QIs in a university hospital setting, including 14 QIs previously validated in a multicentre study and 3 additional QIs. <h3>Material and Methods</h3> Data were collected through a point prevalence study (PPS) by trained specialists in internal medicine and hospital pharmacists in March 2023. Information on demographics, infections, diagnostics and AM therapies was collected. Adult inpatients who received at least one AM on the PPS days were included. The following clinical characteristics were analysed for QI validation: Applicability:% of all cases to which the indicator applies (target &gt; 5%). Feasibility:% of available and valid values per indicator (target &gt; 75%). Performance:% of compliance with an indicator (target &lt; 85%). inter-rater reliability: agreement between different raters (target k &gt; 0,6). <h3>Results</h3> Data from 1027 patients were reviewed on the day of the survey, of whom 426 received at least one AM and were included in the detailed analysis (AM use prevalence: 41.48%). All QIs met the targets for applicability (8.2%-97.5%) and feasibility (93.1%-100.0%), confirming that they are relevant to the minimum amount of therapies. The study also confirmed the feasibility of all QIs (93.1%-100%) meaning that most of the data were available and could be analysed. In terms of performance, 13/17 QIs were found to be within the target of ≤ 85% with five QIs already showing a higher performance &gt; 85%. The Inter-rater reliability was 0,6–1,0, confirming adequate reproducibility. <h3>Conclusion and Relevance</h3> All QIs are applicable in the setting analysed. 13 QIs can be used routinely in the AMS programme, while five QIs need to be redefined in terms of target achievement. <h3>References and/or Acknowledgements</h3> <h3>Conflict of Interest</h3> No conflict of interest