4CPS-107 Evaluation of early oral switch in antimicrobial therapy interventions through the WASPSS programme in the work of PROA teams

<h3>Background and Importance</h3> Within the framework of the National Plan Against Antibiotic Resistance (PRAN), the WASPSS (Wise Antimicrobial Stewardship Programme Support System) application has been implemented in our health area to facilitate the management of antimicrobial treatments (AT) within the Antimicrobial Stewardship Programmes (PROA). This tool generates predefined alerts used by PROA teams (Pharmacy, Microbiology, and Infectious Diseases) to optimise AT. In this analysis, we reviewed the alerts related to intravenous AT longer than 3 days with good oral bioavailability. <h3>Aim and Objectives</h3> To analyse the outcomes of alerts generated for intravenous AT longer than 3 days with good oral bioavailability through the WASPSS application within the PROA program established in our area. <h3>Material and Methods</h3> Data were collected using the WASPSS application from October 1st, 2022, to October 1st, 2024, resulting in a total of 2252 AT-related alerts. These alerts were categorised by patient’s clinical record number, clinical service, treatment, response, action taken, and the responder’s identity. The patient’s clinical record numbers were removed for data analysis. <h3>Results</h3> Of the 2252 alerts registered in WASPSS, this study focused on 227 alerts (10.08% of the total alerts) related to intravenous AT longer than 3 days with the potential for Early Oral Switch (EOS). The clinical services most frequently involved were General and Digestive Surgery (35.24%), Internal Medicine (19.38%), and Haematology (14.1%). The most frequently implicated antibiotics were metronidazole (39.21%), ciprofloxacin (15.86%), and levofloxacin (13.22%). Of the 227 recommendations, 60% were accepted, resulting in the implementation of EOS, and 10% received validation of the treatment. <h3>Conclusion and Relevance</h3> Ten percent of the alerts corresponded to intravenous AT suitable for conversion to oral therapy, of which 60% of the recommendations resulted in the implementation of EOS. The service most frequently involved was General and Digestive Surgery (35.24%), and the most commonly used antibiotic was metronidazole (39.21%), which may be attributed to delays in transitioning to oral therapy after surgical interventions. Nevertheless, the implementation of the WASPSS system has increased the EOS rate in these services. However, efforts are ongoing to optimise the alert-recommendation-response process to improve the precision in EOS management. <h3>References and/or Acknowledgements</h3> <h3>Conflict of Interest</h3> No conflict of interest