5PSQ-044 Abstract withdrawn

<h3>Background and Importance</h3> Adverse Drug Reactions (ADRs) cause 5–10% of hospital admissions and occur in 10–20% of hospitalised patients. <h3>Aim and Objectives</h3> To find out the impact of ADRs on patients’ hospitalisation. <h3>Material and Methods</h3> Retrospective case-control study that included patients’ hospitalisation over 17 years of age during the period 2017–2023, using a clinical administrative national dataset. Cases were defined as hospitalisations with a record of ADRs, in terms of chapter T36-T50 of ICD-10. Controls were the remaining hospitalisations exempt from these ADRs codes. Medians were compared by Wilcoxon test and proportions by Chi2. Two multivariate regression models and two propensity score matching models were constructed to study the influence of ADRs on the length of hospital stay and mortality. <h3>Results</h3> 126,075 hospitalisations were analysed, 117,145 non-ADRs and 8,930 with ADRs during admission. The prevalence of ADRs was 7.08% (95% CI 6.90–7.20). Men were more represented: 53.38% and 51.10%, respectively. The median age in non-ADRs patients was 72 years (IQR 56–82) and 77 (IQR 68–85) in ADRs group, p=0.000. The median van Walraven comorbidity index (WI) was 4 (IQR 2–8) in non-ADRs group and 7 (4–13) in ADRs patients. Patients without ADRs were admitted for a median of 4 days (IQR 2–8) versus 7 (IQR 4–13) in ADRs group. Mortality rate during admission in non-ADRs group was 4.73% (95%IC 4.60–4.90) versus 6.55% (95%IC 6.00–7.10) in ADRs group. Age (OR=1.05, IC95% 1.03–1.06; p=0.000), female sex (OR=1.15, 95% IC 1.10–1.20; p=0.000), length of stay (OR=1.54, 95% IC 1.51–1.57; p=0.000) and comorbidity measured by IW (OR=1.60, 95%IC 1.56–1.63; p=0.000) increased the likelihood of ADRs. Using sex, age and IW as covariates, ADRs were associated with increased length of hospital stay: IRR (Increased Relative Risk) =1.412 (95%IC 1.376–1.448), p=0.000. However, ADRs were not associated with higher mortality rate: OR= 0.807 (95%IC 0.743–0.877), p=0.000. The <i>matching</i> test obtained an increase of 3.226 days in length of stay compared to a control patient of the same sex, age and comorbidity free of ADRs: Coefficient= 3.33 (95%IC 2.922–3.532), p=0.000 but also shows no increase in mortality: Coefficient= (-)0.007 (95%IC (-)0.12- (-)0.026), p=0.003. <h3>Conclusion and Relevance</h3> Patients with ADRSs are older and have more comorbidity. ADRSs are associated with increase length of hospital stay but advanced analysis shows no increase in mortality. <h3>References and/or Acknowledgements</h3> <h3>Conflict of Interest</h3> No conflict of interest