Mediators of the association between allergic diseases and bronchiectasis: A bi-directional univariable and multivariable Mendelian randomization study and mediation analysis
Our findings suggest that allergic asthma, allergic rhinitis, atopic conjunctivitis, and atopic dermatitis increase the risk of developing bronchiectasis, with no evidence of a reverse causal relationship. Specifically, 3 metabolic ratios were identified as mediators between allergic diseases and bronchiectasis. Further studies are needed to clarify the underlying mechanisms.
Authors
- Jie‐Lin Wang
- Shinian Fu (ORCID: https://orcid.org/0000-0003-3522-9908)
- Jing Li (ORCID: https://orcid.org/0000-0002-3977-1641)
- Hui Luo (ORCID: https://orcid.org/0000-0001-6312-9299)
- Rui Qin (ORCID: https://orcid.org/0000-0003-4093-7044)
- Pingan Zhang
Institutions
- First Affiliated Hospital of Guangzhou Medical University (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- World Allergy Organization Journal
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.waojou.2025.101038
- Citations
- 4
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.66
Funders
- National Natural Science Foundation of China