Clinical manifestations of thrombomodulin dysfunction

Thrombomodulin (TM) performs a wide variety of functions: it is involved in the regulation of hemostatic answer, inflammation, cell proliferation and angiogenesis. Studying clinical manifestations of thrombomodulin dysfunction helps to better understand its role in various physiological processes and develop new treatment strategies involving the use of thrombomodulin. Here, we focused on genetic causes of this problem, describing some pathological mutations in the TM gene as well as their clinical manifestations. We also reported on TM use in disease diagnosis and treatment and discussed the prospects for its application in the management of various life-threatening conditions.