The Frequency and Potential Implications of <i>HFE</i> Genetic Variants in Children With Cystic Fibrosis
Our study revealed that the presence of HFE variant C282Y in people with CF may lead to more severe lung disease manifestations beginning in early childhood. There is a risk of hemochromatosis in CF patients with two HFE variants, and thus they should be followed for evidence of iron overload.
Authors
- Elizabeth A. Worthey (ORCID: https://orcid.org/0000-0003-4083-7764)
- G. Sawicki (ORCID: https://orcid.org/0000-0003-3356-709X)
- Leslie Huang (ORCID: https://orcid.org/0000-0001-9778-8102)
- Fadi Asfour (ORCID: https://orcid.org/0000-0001-6317-6845)
- HuiChuan J. Lai (ORCID: https://orcid.org/0000-0001-8084-3988)
- Michael J. Rock (ORCID: https://orcid.org/0000-0001-9665-1737)
- Michelle S. Howenstine
- Nicholas Antos (ORCID: https://orcid.org/0000-0002-7380-120X)
- K. Boyne
- Jonathan M. Gaffin (ORCID: https://orcid.org/0000-0003-2213-4504)
- Philip M. Farrell (ORCID: https://orcid.org/0000-0003-0036-7016)
- Katryn N. Furuya (ORCID: https://orcid.org/0000-0002-7575-4443)
Institutions
- Northwestern University (US)
- Boston Children's Hospital (US)
- University of Wisconsin–Madison (US)
- Medical College of Wisconsin (US)
- University of Utah (US)
- University of Alabama at Birmingham (US)
- Indiana University Indianapolis (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Pediatric Pulmonology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/ppul.71042
- Citations
- 1
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- Cystic Fibrosis Foundation
- University of Minnesota
- Legacy of Angels Foundation
- National Institutes of Health
- School of Medicine and Public Health, University of Wisconsin-Madison