Analytical Characterization and Validation of a Novel Automated Amino-Terminal proB-Type Natriuretic Peptide Assay
A method comparison showed good harmony with an established assay, and analytic parameters demonstrated satisfactory overall performance. Imprecision across the measurement range is <8%. The Access NT-proBNP assay yielded age-specific 97.5th percentile URLs in harmony with the Elecsys reference method. The Access NT-proBNP assay demonstrated robust analytical performance that is fit for the purpose of supporting an NT-proBNP clinical trial for HF diagnosis and prognosis.
Authors
- W. Franklin Peacock
- Brandon R. Allen (ORCID: https://orcid.org/0000-0003-2577-016X)
- Jenny Guidi (ORCID: https://orcid.org/0000-0001-6815-2738)
- Robert H. Christenson (ORCID: https://orcid.org/0000-0003-2612-9083)
- Dileepa Alahapperuma
- James Louis Januzzi (ORCID: https://orcid.org/0000-0002-8338-1798)
- Gary Headden
- Nicole Winden
Institutions
- University of Maryland, Baltimore (US)
- Medical University of South Carolina (US)
- Baylor College of Medicine (US)
- Brown University (US)
- University of Florida (US)
- Massachusetts General Hospital (US)
- Baim Institute for Clinical Research (US)
- Beckman Coulter Foundation (US)
Publication Details
- Journal
- The Journal of Applied Laboratory Medicine
- Published
- 2025-02-03
- DOI
- https://doi.org/10.1093/jalm/jfaf012
- Citations
- 2
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 2.78