4-phenylbutyric acid attenuates diabetes mellitus secondary to thiamine-responsive megaloblastic anaemia syndrome by modulating endoplasmic reticulum stress
THTR-1 deficiency triggers diabetes in TRMA patients through ERS, and 4-PBA protects pancreatic islet β-cells by inhibiting ERS, which provides new ideas and intervention targets for the prevention and treatment of TRMA and diabetes.
Authors
- Yumei Qin
- Yuping Ye (ORCID: https://orcid.org/0000-0002-3116-9410)
- Faquan Lin (ORCID: https://orcid.org/0000-0002-8631-4339)
- Min Chen (ORCID: https://orcid.org/0000-0002-0960-4447)
- Xuan Zhang
- Yuanyuan Qin (ORCID: https://orcid.org/0000-0002-8168-3573)
Institutions
- Guangxi Medical University (CN)
- Liuzhou Maternal and Child Health Hospital (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Endokrynologia Polska
- Published
- 2025-02-26
- DOI
- https://doi.org/10.5603/ep.101404
- Citations
- 1
- Primary Topic
- Alcoholism and Thiamine Deficiency
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangxi Province