Exploring the Synergistic Potential of Flavone and Niacin in Depression Treatment

A BSTRACT Context: Depression is a complicated and crippling mood illness that still poses problems for doctors and researchers around the globe. Even with the abundance of available treatments, many patients still encounter unfavorable side effects and low efficacy. Methodology: Models such as the sucrose test (anhedonia) and the social deficit test were chosen. Natural substances have drawn interest recently because of their possible antidepressant qualities. Through different modes of action, flavone, a subclass of flavonoids that is plentiful in fruits and vegetables, and niacin (Vitamin B3), a water-soluble vitamin found in a variety of foods, have each showed promise in reducing symptoms of depression. This study examines the growing body of data regarding the synergistic potential and underlying mechanisms of flavone and niacin together as therapeutic agents in the treatment of depression. Niacin and flavone dosages were chosen in a 1:2 ratio, or 25 + 50 = 75 mg/kg/b.w., based on their effectiveness and safety to give depression significant attention. Results: The results of this study indicated that niacin and flavone had a synergistic effect. In sucrose test, the level of consumption of sugar water moderately increased compared to the control group, and interaction with animals was increased to four-folds than control. Niacin acts by serotonin modulator, and flavone is purely an efficient antioxidant agent, together with anti-inflammatory and neuroprotective properties, it becomes the perfect choice in alleviating depression at bay. Conclusion: To sum up the combination of flavone and niacin can be used as an effective alternative in treating depression naturally. Due to its availability in nature and less side effects, it lays the foundation for developing the precise and efficient complementary treatment.