STING‐Activating Polymers Boost Lymphatic Delivery of mRNA Vaccine to Potentiate Cancer Immunotherapy (Adv. Mater. 10/2025)
Cancer Vaccine In article number 2412654, Qianqian Ni, Xiaoyuan Chen, Longjiang Zhang, and their team present a novel STING-activating polymer (PD) to enhance mRNA vaccine immunogenicity. By incorporating PD polymer into lipid nanoparticle, the resulted vehicle (PD LNP) improved lymphatic delivery and immune activation of mRNA cancer vaccine, demonstrating the promising potential of PD LNPs for cancer immunotherapy.
Authors
- Ling Peng (ORCID: https://orcid.org/0000-0003-3990-5248)
- Benhao Li
- Shengqi Chen (ORCID: https://orcid.org/0000-0002-5680-0942)
- Yenhui Ong
- Bowei Yang
- Xiaolin Han (ORCID: https://orcid.org/0000-0001-9721-5371)
- Ling‐Wen Ding (ORCID: https://orcid.org/0000-0003-0022-1551)
- Mengyao Zhao (ORCID: https://orcid.org/0000-0002-5038-8504)
- Yaxin Hu (ORCID: https://orcid.org/0000-0002-5952-9318)
- Yongling Wang (ORCID: https://orcid.org/0000-0002-0474-4782)
- Jianping Liu (ORCID: https://orcid.org/0000-0002-0320-061X)
- Miao Zhang (ORCID: https://orcid.org/0000-0003-4912-2570)
- Xiaoyuan Shawn Chen (ORCID: https://orcid.org/0000-0002-9622-0870)
- Bingyu Li (ORCID: https://orcid.org/0000-0002-3013-2501)
- Zhaoming Wu (ORCID: https://orcid.org/0000-0002-1429-6653)
- Longjiang Zhang (ORCID: https://orcid.org/0000-0002-7380-6991)
- Qianqian Ni (ORCID: https://orcid.org/0000-0003-4230-5059)
- Jianwei Li
- Min Luo (ORCID: https://orcid.org/0000-0001-8726-0355)
- Kongfu Zhu
Institutions
- Centre National de la Recherche Scientifique (FR)
- National University of Singapore (SG)
- Zunyi Medical University (CN)
- Aix-Marseille Université (FR)
- Nanjing General Hospital of Nanjing Military Command (CN)
- Centre Interdisciplinaire de Nanoscience de Marseille (FR)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Advanced Materials
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/adma.202570078
- Citations
- 1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80