NCCN Guidelines® Insights: Myelodysplastic Syndromes, Version 2.2025
The NCCN Guidelines for Myelodysplastic Syndromes (MDS) provide recommendations for the evaluation, diagnosis, and comprehensive care of patients with MDS based on a review of recent clinical evidence that has led to important advances in treatment or has yielded new information on biologic factors that may have prognostic significance in MDS. The multidisciplinary panel of MDS experts is convened at least on an annual basis. During the annual meeting, the panel evaluates new and emerging data to inform their recommendations. These NCCN Guidelines Insights review the recent updates, including treatment recommendations both for lower-risk and higher-risk MDS, preference stratification of therapeutic agents, and emerging data on novel therapeutics.
Authors
- Aref Al‐Kali (ORCID: https://orcid.org/0000-0002-0824-3715)
- Andrew Mark Brunner (ORCID: https://orcid.org/0000-0002-2169-4115)
- Yasmin Abaza (ORCID: https://orcid.org/0000-0002-9156-7912)
- Tiffany Tanaka (ORCID: https://orcid.org/0000-0002-7656-5249)
- Uma Borate (ORCID: https://orcid.org/0000-0002-4958-4962)
- Vishnu Reddy (ORCID: https://orcid.org/0000-0001-5474-3289)
- Zhubin Gahvari
- Jamie Nguyen (ORCID: https://orcid.org/0000-0002-5491-8701)
- David Andrew Sallman (ORCID: https://orcid.org/0000-0003-0504-8233)
- Amy Elizabeth Dezern (ORCID: https://orcid.org/0000-0001-5225-4609)
- Abhay Singh (ORCID: https://orcid.org/0000-0001-6657-8647)
- Hamid Sayar (ORCID: https://orcid.org/0000-0002-1047-8783)
- Lori J. Maness
- Cindy Hochstetler
- Rashmi Khanal
- Brian Ball (ORCID: https://orcid.org/0000-0001-8625-7023)
- Olatoyosi M. Odenike (ORCID: https://orcid.org/0000-0002-4027-4124)
- Elizabeth A. Griffiths (ORCID: https://orcid.org/0000-0002-0288-8248)
- Ashwin Kishtagari (ORCID: https://orcid.org/0000-0003-1149-4571)
- Peter Curtin (ORCID: https://orcid.org/0009-0007-1853-3752)
- John M. Bennett (ORCID: https://orcid.org/0000-0001-7517-5567)
- Swapna Thota (ORCID: https://orcid.org/0000-0002-4216-1414)
- Sarah Anand (ORCID: https://orcid.org/0009-0002-2268-9008)
- Brian A. Jonas (ORCID: https://orcid.org/0000-0002-4921-5809)
- Shannon R. McCurdy (ORCID: https://orcid.org/0000-0002-2813-6781)
- Christine M. McMahon (ORCID: https://orcid.org/0000-0001-9745-9595)
- Wanxing Chai‐Ho (ORCID: https://orcid.org/0000-0002-0657-836X)
- Richard Maury Stone (ORCID: https://orcid.org/0000-0002-7526-2633)
- Tamanna Zohra Haque (ORCID: https://orcid.org/0009-0001-7999-5842)
- Yazan F. Madanat (ORCID: https://orcid.org/0000-0001-9573-2690)
- Rory Michael Shallis (ORCID: https://orcid.org/0000-0002-8542-2944)
- Sioḃán Keel (ORCID: https://orcid.org/0000-0002-9599-8226)
- Guillermo Garcia-Manero
- P Greenberg
- Karin Gaensler
- Afaf Osman
- Meagan A. Jacoby
- Emily Kovach
Institutions
- Fox Chase Cancer Center (US)
- Roswell Park Comprehensive Cancer Center (US)
- Barnes-Jewish Hospital (US)
- City Of Hope National Medical Center (US)
- St. Jude Children's Research Hospital (US)
- Cleveland Clinic (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Tennessee Health Science Center (US)
- Breast Cancer Research Foundation (US)
- University of Utah (US)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- UC San Diego Health System (US)
- Huntsman Cancer Institute (US)
- Cancer Institute (WIA) (IN)
- Susan Thompson Buffett Foundation (US)
- WinnMed (US)
- Yale Cancer Center (US)
- Moffitt Cancer Center (US)
- Massachusetts General Hospital (US)
- Fred Hutch Cancer Center (US)
- Southwestern Medical Center (US)
- Jewish Hospital (US)
- University of Wisconsin Carbone Cancer Center (US)
- Sidney Kimmel Cancer Center (US)
- University Hospitals Seidman Cancer Center (US)
- University of Colorado Cancer Center (US)
- Dana-Farber Brigham Cancer Center (US)
- Smilow Cancer Hospital (US)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Indiana University Melvin and Bren Simon Comprehensive Cancer Center
- Moores Cancer Center
- University of Chicago Medicine Comprehensive Cancer Center
- UCLA Jonsson Comprehensive Cancer Center
- Vanderbilt-Ingram Cancer Center
- Stanford Cancer Institute
- Fred and Pamela Buffett Cancer Center
- UC Davis Comprehensive Cancer Center
- Harold C. Simmons Comprehensive Cancer Center
- O'Neal Comprehensive Cancer Center
- National Comprehensive Cancer Network
- University of Rochester (US)
- Indiana University (US)
- University of Pennsylvania (US)
- University of California, Davis (US)
- The University of Texas Southwestern Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of the National Comprehensive Cancer Network
- Published
- 2025-03-01
- DOI
- https://doi.org/10.6004/jnccn.2025.0013
- Citations
- 12
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 21.24