Distance matters: How protein regulators facilitate enhancer-promoter interactions and transcription
Cohesin, transcription factors (TFs), and mediator complex components regulate gene expression partly by regulating enhancer-promoter (E-P) communication. A new study combined E-P distance-controlled reporter screens with the inhibition or degradation of regulatory proteins and uncovered a distance-dependent effect across cohesin, TFs, and mediator complex components.
Authors
- Masahiro Nagano (ORCID: https://orcid.org/0000-0003-1228-4015)
- Anders S. Hansen (ORCID: https://orcid.org/0000-0001-7540-7858)
Institutions
- Broad Institute (US)
- Kyoto University (JP)
- Foundation Center (US)
- Novo Nordisk (United States) (US)
- Allen Institute (US)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Cell Genomics
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.xgen.2025.100817
- Citations
- 1
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Science Foundation
- Broad Institute
- Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Novo Nordisk
- Daiichi Sankyo Foundation of Life Science
- Novo Nordisk Fonden
- National Institutes of Health
- Daiichi Sankyo Europe