Enhancement of plasma kallikrein specificity of antitrypsin variants identified by phage display and partial reversion
Pro substitution at P4 was found to be important for enhanced inhibition of Pka by AAT M358R. Two novel variants with this substitution are more rapid and selective inhibitors of Pka than AAT M358R and may provide better control of Pka in vivo than existing HAE therapeutics.
Authors
- Toshiyuki Seto (ORCID: https://orcid.org/0000-0002-9202-6595)
- Varsha Bhakta (ORCID: https://orcid.org/0000-0002-0698-072X)
- Sangavi Sivananthan
- William P. Sheffield (ORCID: https://orcid.org/0000-0002-5870-8189)
- Negin Chaechi Tehrani
Institutions
- Canadian Blood Services (CA)
- McMaster University (CA)
Publication Details
- Journal
- BMC Biotechnology
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1186/s12896-025-00956-8
- Citations
- 1
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Canadian Blood Services