Establishment and application of a wild neonatal mouse model infected with an Echovirus 30 isolate
In summary, this research established a wild neonatal mouse model of E30/A538 isolate infection that mirrors the characteristics of human infection. The model demonstrated the efficacy of interferon-α2a in combating E30. This model would serve as a foundation for investigating the pathogenesis of E30, as well as for assessing the efficacy of vaccines and other antiviral treatments against E30.
Authors
- Huanying Zheng (ORCID: https://orcid.org/0000-0002-2928-548X)
- Ning Zhang (ORCID: https://orcid.org/0000-0001-5244-9369)
- Shengjun Xiao (ORCID: https://orcid.org/0000-0001-6731-1899)
- Ying Qu (ORCID: https://orcid.org/0000-0002-6763-4601)
- Qiliang Liu (ORCID: https://orcid.org/0000-0002-4684-8504)
- Yongbei Chen
- Hongbo Liu (ORCID: https://orcid.org/0000-0002-7915-9596)
- Jing Wang (ORCID: https://orcid.org/0000-0002-4122-5471)
- Yunyi He
Institutions
- Guilin Medical University (CN)
- Guangdong Provincial Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1186/s12985-025-02684-z
- Citations
- 2
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- National Natural Science Foundation of China