Prediction of long-term HBsAg seroclearance in patients with HBeAg-negative chronic hepatitis B
Achieving a functional cure for chronic hepatitis B, defined as HBsAg seroclearance, is a realistic treatment endpoint, especially given the virus's lifelong persistence in hepatocytes and its significant association with improved prognosis. This study identified independent predictors of seroclearance, including HBV DNA levels, age, sex, and HBsAg levels, and developed a robust prediction model based on these factors. The models demonstrated strong predictive accuracy over a 15-year period, offering valuable guidance for clinicians in establishing treatment strategies and predicting patient prognosis.
Authors
- Ji Won Han (ORCID: https://orcid.org/0000-0003-1456-1450)
- Do Seon Song (ORCID: https://orcid.org/0000-0002-8278-4878)
- Pil Soo Sung (ORCID: https://orcid.org/0000-0002-5780-9607)
- Si Hyun Bae (ORCID: https://orcid.org/0000-0003-1727-7842)
- Jeong Won Jang (ORCID: https://orcid.org/0000-0003-3255-8474)
- Soon Kyu Lee (ORCID: https://orcid.org/0000-0003-1865-8225)
- Seung Kew Yoon (ORCID: https://orcid.org/0000-0002-4476-4868)
- Chang Wook Kim (ORCID: https://orcid.org/0000-0003-1184-0358)
- Hyun Yang (ORCID: https://orcid.org/0000-0001-6588-9806)
- Jung Hyun Kwon (ORCID: https://orcid.org/0000-0002-5484-5864)
- Jong Young Choi (ORCID: https://orcid.org/0000-0001-7833-0307)
- Hae Lim Lee (ORCID: https://orcid.org/0000-0002-3242-8883)
- Heechul Nam (ORCID: https://orcid.org/0000-0001-5421-6868)
- Sung Won Lee
- Hee Yeon Kim (ORCID: https://orcid.org/0000-0001-9669-5705)
Institutions
- Catholic University of Korea (KR)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101391
- Citations
- 4
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.42