Trained immunity using probiotics and inactivated pathogens enhances resistance to Salmonella enterica serovar Typhimurium infection by activating the cGAS-STING signal pathway in mice and chickens
Trained immunity activated by probiotics and inactivated bacterial pathogens enhanced resistance against S. Typhimurium infection via macrophage activation and involved the cGAS-STING pathway. These findings highlight the potential of trained immunity as an alternative strategy for disease prevention in both livestock and poultry.
Authors
- Junpeng Jia
- Wei Ji (ORCID: https://orcid.org/0000-0002-4417-8877)
- Nian Xiong (ORCID: https://orcid.org/0000-0003-1371-0522)
- Jian Lin (ORCID: https://orcid.org/0000-0003-0455-9736)
- Qian Yang
Institutions
- Nanjing Agricultural University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1016/j.jare.2025.03.011
- Citations
- 4
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- National Natural Science Foundation of China
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Fundamental Research Funds for the Central Universities