Synthesis of Heteroatom‐Containing Organic Molecules <i>via</i> Intramolecular Cross‐Dehydrogenative Coupling

Abstract Heterocyclic compounds or heterocycles constitute the most prominent class of organic chemistry. The extensive functional utility of these compounds in pharmaceuticals and material science has led to increased research interest in this area. Since heteroatom containing molecules hold a pivotal position in both chemistry and biology, a number of methodologies have already been known for their synthesis. However, advancement in the synthetic methodology for their construction under mild reaction conditions is highly important. In the current scenario of research, intramolecular cross‐dehydrogenative coupling has emerged as a promising strategy in the synthesis of complex organic molecules from simpler ones via direct C−H functionalization. This one‐pot atom‐economic protocol can construct fused heterocycles that are both pharmaceutically and medicinally important. The present review focuses on transition‐metal free synthesis of heteroatom containing organic molecules intramolecularly through carbon‐carbon (C−C) and carbon‐heteroatom (C−X) bond formation reactions reported over past one decade.