Identifying distinct prognostic and predictive contributions of tumor epithelium versus tumor microenvironment in colorectal cancer
Here we identified a pair of new, distinct 10-gene signatures (the EPI<sup>S</sup> vs. the TME<sup>S</sup>) capable of distinguishing the cellular contribution of the tumor EPI vs. the TME in determining CRC prognosis and therapeutic outcomes. With targeted approaches emerging to address both tumor epithelial cells and the TME, the EPI<sup>S</sup> vs. TME<sup>S</sup> signature scores may have a novel biomarker role to permit optimization of CRC therapy by identifying sensitive vs. resistant subpopulations.
Authors
- Mingli Yang (ORCID: https://orcid.org/0000-0002-4781-690X)
- Ramani Soundararajan (ORCID: https://orcid.org/0000-0001-6408-2840)
- Sanjay Goel (ORCID: https://orcid.org/0000-0002-2798-7568)
- Ashley J. Alden (ORCID: https://orcid.org/0009-0007-8920-2467)
- Michelle M. Maurin (ORCID: https://orcid.org/0009-0005-4777-2504)
- Michael Nebozhyn (ORCID: https://orcid.org/0000-0001-8835-7714)
- Michael J. Schell (ORCID: https://orcid.org/0000-0003-4594-6601)
- Andrey Loboda (ORCID: https://orcid.org/0000-0003-4239-184X)
- Lance Pflieger (ORCID: https://orcid.org/0000-0003-2237-5674)
- Emil Lou (ORCID: https://orcid.org/0000-0002-1607-1386)
- Nishant Gandhi (ORCID: https://orcid.org/0009-0003-0560-5543)
- George W. Sledge (ORCID: https://orcid.org/0000-0003-0297-0775)
- Domenico Coppola (ORCID: https://orcid.org/0000-0001-9090-1205)
- Heiman Wang (ORCID: https://orcid.org/0009-0007-5799-8982)
- Moh’d Khushman (ORCID: https://orcid.org/0000-0002-3095-5073)
- Andrew Elliott (ORCID: https://orcid.org/0009-0001-9302-8189)
- Jetsen Rodriguez Silva
- W. J. Pledger
- Timothy Joseph Yeatman (ORCID: https://orcid.org/0000-0002-7487-0784)
Institutions
- Rutgers, The State University of New Jersey (US)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Washington University in St. Louis (US)
- University of South Florida (US)
- Tampa General Hospital (US)
- Moffitt Cancer Center (US)
- Florida Digestive Health Specialists (US)
- Université Bourgogne Franche-Comté (FR)
- University of Minnesota Medical Center (US)
- Caris Life Sciences (United States) (US)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1186/s12885-025-13829-2
- Citations
- 3
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- National Institutes of Health