Dabigatran Combined With Benztropine Ameliorates Cobalt Chloride-Induced Parkinsonism in Rats, Restores Protease-Activated Receptor 1 (PAR1), and Mitigates Oxidative Stress
BM+DE offers a therapeutic potential for parkinsonism triggered by chronic exposure to CoCl<sub>2</sub>. The implication of thrombin-related factors and oxidative stress in the modulation of the dopaminergic-adenosinergic crosstalk is plausible.
Authors
- Soha Elmorsy (ORCID: https://orcid.org/0000-0003-2947-9353)
- Walaa Mohamed Sayed (ORCID: https://orcid.org/0000-0002-8427-4468)
- Sherine Abdelmissih (ORCID: https://orcid.org/0000-0002-6426-9813)
- Laila A. Rashed (ORCID: https://orcid.org/0000-0001-8534-7174)
- Hesham Mahmoud (ORCID: https://orcid.org/0000-0001-7685-2750)
- Mohamed Sharif Ismail Negm
Institutions
- Cairo University (EG)
Publication Details
- Journal
- Cureus
- Published
- 2025-03-12
- DOI
- https://doi.org/10.7759/cureus.80486
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39