Long-Term Latency of Highly Mutated Cells in Normal Mouse Skin Is Reversed by Exposure to Tumor Promoters and Chronic Tissue Damage
Using historical skin cancer models, we reveal that mutated cells can persist without tumor formation and give rise to cancer upon exposure to tumor promoters, underscoring the importance of tumor promotion over initiation as the rate-limiting step in carcinogenesis and the need for cancer prevention strategies targeting promotional factors. See related commentary by Lim and DeGregori, p. 1090.
Authors
- Kavya Achanta (ORCID: https://orcid.org/0009-0004-3631-5845)
- Melissa Quino Reeves (ORCID: https://orcid.org/0000-0002-4886-5164)
- Laura Riva (ORCID: https://orcid.org/0000-0001-5688-4915)
- Erik N. Bergstrom (ORCID: https://orcid.org/0000-0001-7740-022X)
- Olga K. Mirzoeva (ORCID: https://orcid.org/0000-0002-5564-1564)
- Kyle Halliwill (ORCID: https://orcid.org/0000-0001-5513-4725)
- S. M. Ashiqul Islam (ORCID: https://orcid.org/0000-0002-5686-6474)
- Allan Balmain (ORCID: https://orcid.org/0000-0001-6549-7861)
- Reyno Delrosario
- Ludmil B. Alexandrov (ORCID: https://orcid.org/0000-0003-3596-4515)
- Eve Kandyba (ORCID: https://orcid.org/0000-0002-9219-5284)
- John DiGiovanni (ORCID: https://orcid.org/0000-0003-4233-6728)
- Quân Tran (ORCID: https://orcid.org/0000-0002-5769-3480)
- Di Wu (ORCID: https://orcid.org/0009-0001-7369-0220)
- Nora Bayani
Institutions
- Albany State University (US)
- Austin College (US)
- Translational Genomics Research Institute (US)
- City Of Hope National Medical Center (US)
- University of California, San Francisco (US)
- University of Utah (US)
- Wellcome Sanger Institute (GB)
- University of California San Diego (US)
- University at Albany, State University of New York (US)
- City of Hope (US)
- La Jolla Bioengineering Institute (US)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- The University of Texas at Austin (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-1379
- Citations
- 6
- Primary Topic
- Science, Research, and Medicine
- Type
- article
- Field-Weighted Citation Impact
- 10.19