Decreased complement 4 and interleukin-10 as biomarkers in aqueous humour for non-exudative age-related macular degeneration: a case control study
This pilot study presents an initial overview of inflammation-associated biomarkers in the aqueous humour, highlighting potential roles for C4 and IL-10 in the development of non-exudative AMD. A larger, more-focused follow-up study is in progress to further investigate biomarkers localised to the eye and refine our understanding of AMD.
Authors
- Richard B. Pouw (ORCID: https://orcid.org/0000-0003-3469-8454)
- Christian van Oterendorp (ORCID: https://orcid.org/0009-0000-3237-3803)
- Jannis Klemming
- Mihály Józsi (ORCID: https://orcid.org/0000-0002-5520-5535)
- Nicolas Feltgen (ORCID: https://orcid.org/0000-0002-6857-3003)
- Hannah N. Wolf
- Thomas Bertelmann (ORCID: https://orcid.org/0000-0002-4017-2224)
- Diana Pauly (ORCID: https://orcid.org/0000-0002-1563-1601)
- Juliane Schikora (ORCID: https://orcid.org/0009-0007-1251-9175)
- Dirk Bahlmann
- Aaron Dort
- Hans Hoerauf
Institutions
- Eötvös Loránd University (HU)
- Philipps University of Marburg (DE)
- Sanquin (NL)
- Universitätsmedizin Göttingen (DE)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1186/s12967-024-05909-x
- Citations
- 3
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.12
Funders
- Philipps-Universität Marburg
- H2020 Future and Emerging Technologies