Bradykinin’s carbamylation as a mechanistic link to impaired wound healing in patients with kidney dysfunction
Carbamylation-driven impairment of wound healing is a mechanistic link to wound persistence in uremia. Importantly, production of carbamylated bradykinin in localized inflammatory milieus could be a significant contributor to delayed wound healing and formation of chronic wounds in diabetes or psoriasis.
Authors
- Eleni Skandalou
- Małgorzata Benedyk‐Machaczka
- Marta Kamińska (ORCID: https://orcid.org/0000-0002-8299-7603)
- Melissa M. Grant (ORCID: https://orcid.org/0000-0003-1154-7266)
- Piotr Mydel (ORCID: https://orcid.org/0000-0001-5072-9391)
- Janka Bábíčková (ORCID: https://orcid.org/0000-0001-7859-9242)
- Urszula Kałucka (ORCID: https://orcid.org/0000-0002-5274-308X)
- Hans-Peter Marti
Institutions
- Jagiellonian University (PL)
- Haukeland University Hospital (NO)
- University of Bergen (NO)
- University of Birmingham (GB)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1186/s12915-025-02187-x
- Citations
- 1
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Narodowe Centrum Nauki
- L. Meltzers Høyskolefond