A Case Report of Pulmonary Tumor Thrombotic Microangiopathy Caused by Lung Adenocarcinoma: The Importance of Clinical Diagnosis and Monitoring Disease Progression

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare and fatal lung complication associated with cancer. Diagnosing PTTM is challenging due to its rapid progression and nonspecific clinical or imaging findings, which often result in postmortem identification. Treatment options are limited, and long-term management remains poorly understood. This report describes a 50-year-old patient with lung adenocarcinoma who was clinically diagnosed with PTTM and showed improvement with early chemotherapy initiation. Disease activity was controlled through multiple chemotherapy regimens, and recurrence was monitored using blood coagulation status and echocardiography. This case highlights the importance of early clinical diagnosis and ongoing monitoring of disease progression in PTTM.