Pseudobulbar affect: clinical associations, social impact and quality of life implications - Lessons from PLS

Despite sporadic reports, the clinical, social, caregiver burden and quality of life implications of pseudobulbar affect remain poorly characterised. The comprehensive evaluation of the clinical correlates of PBA helps to elucidate the underlying pathophysiology. Ultimately, the comprehensive assessment of both the aetiology and social impact of PBA helps to raise awareness of this entity, reduce misdiagnoses, enhance the early recognition of this phenomenon and encourage proactive pharmacological intervention.