Effects of the combination of Korean pears and chlorella on endocrine-disrupting chemicals and fat and muscle health

Korean pears and Chlorella have shown potential in detoxifying various xenobiotics. Thus, we investigated their combined effects on the detoxification of endocrine-disrupting chemicals (EDCs), and EDC-related fat and muscle health using a non-inferiority clinical trial and in vivo and in vitro tests. The human doses of pear extracts, chlorella, and positive control ( l -carnitine tartrate) were safe levels, based on previous clinical trials and the approvement by Korean government. The combination increased hand grip strength. Total cholesterol, low-density lipoprotein, apoA-I, and apoB levels were alleviated by the combination, which also modulated ACC, FASN, and HSL to affect fatty acid synthesis and lipidosis or β-oxidation in high-fat-diet- and bisphenol-A-treated mice and in 3 T3-L1 adipocytes. Consistently, in vitro experiments showed that the combination treatment suppressed adipocyte differentiation, downregulated PPARγ expression, promoted lipid breakdown, and enhanced myoblast differentiation. In conclusion, the combination can be useful to prevent from EDCs on fat and muscle health. • The combination of pears and chlorella reduces internal bisphenol A in mice. • The combination modulates gene expression for fatty acid synthesis and lipidosis. • The combination enhances hand grip strength and MyoG for muscle differentiation. • The combination improved lipid profiles, e.g., TC, LDL-C, apoA-I and apoB.