Fatty acid metabolism shapes immune responses in chronic lymphocytic leukemia
The present study constructed a prognostic risk score based on FAM gene expression, revealing related immune phenotypic differences and exploring the regulatory role of FAO in CLL development. Targeting fatty acid metabolism potentially modulates the CLL immune microenvironment and synergistically enhances the efficacy of PI3K inhibitors.
Authors
- Yang Han (ORCID: https://orcid.org/0000-0001-9501-7814)
- Xiaosheng Fang (ORCID: https://orcid.org/0000-0003-3387-4532)
- Yang Zhang (ORCID: https://orcid.org/0000-0001-5794-5185)
- Xin Wang (ORCID: https://orcid.org/0000-0002-5122-2418)
- Peipei Li (ORCID: https://orcid.org/0000-0001-8246-4578)
- Jun Ma (ORCID: https://orcid.org/0000-0002-2213-3176)
- Ya Zhang (ORCID: https://orcid.org/0000-0003-0894-4922)
- Xinting Hu
- Kang Lu (ORCID: https://orcid.org/0000-0002-7268-0047)
Institutions
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Biomarker Research
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1186/s40364-025-00753-7
- Citations
- 3
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 4.88
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Shandong Province