Macrophage-derived mitochondria-rich extracellular vesicles aggravate bone loss in periodontitis by disrupting the mitochondrial dynamics of BMSCs
The transfer of mitochondria to BMSCs via MEVs exacerbates alveolar bone resorption through LCN2/OMA1/OPA1 signaling in periodontitis. Inhibition of LCN2 alleviates inflammatory bone loss, suggesting a promising therapeutic strategy for periodontitis.
Authors
- Cheng Hu (ORCID: https://orcid.org/0000-0003-1265-2674)
- Jiali Tan
- Danfeng Li (ORCID: https://orcid.org/0000-0001-6894-6765)
- Yang Tian (ORCID: https://orcid.org/0000-0003-1123-602X)
- Jiayin Yan
- Siyuan Ma (ORCID: https://orcid.org/0000-0001-6760-2450)
Institutions
- Sun Yat-sen University (CN)
- Hospital of Stomatology, Sun Yat-sen University
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1186/s12951-025-03178-4
- Citations
- 12
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 9.67
Funders
- National Natural Science Foundation of China