Mesenchymal cell-derived exosomes and miR-29a-3p mitigate renal fibrosis and vascular rarefaction after renal ischemia reperfusion injury
HucMSC-exos, particularly those overexpressing miR-29a-3p, have potent therapeutic effects against renal fibrosis and vascular rarefaction post-I/R. MiR-29a-3p targets TNFR1 and collagen I, highlighting its potential in renal fibrosis therapy.
Authors
- Dingping Yang (ORCID: https://orcid.org/0000-0003-3458-8319)
- Xiongfei Wu (ORCID: https://orcid.org/0000-0001-5977-3401)
- Jiefu Zhu (ORCID: https://orcid.org/0000-0001-9105-022X)
- Rengui Chen
- Fan Zhao (ORCID: https://orcid.org/0000-0002-6677-8857)
- Shangting Han (ORCID: https://orcid.org/0000-0002-1429-4009)
- Lang Shi
- Jing Huang (ORCID: https://orcid.org/0009-0002-7218-9845)
- Yifei Yang (ORCID: https://orcid.org/0000-0002-6210-8557)
- Wenliang Liao (ORCID: https://orcid.org/0009-0008-0298-4046)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1186/s13287-025-04226-4
- Citations
- 11
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 8.87