High-altitude chronic hypoxia prevents myocardial dysfunction in experimental model of type 2 diabetes
CHH exerted cardioprotective effects by improving LV function, increasing myocardial strain and attenuating cardiac hypertrophy in type 2 diabetic rats, likely through reducing apoptosis and oxidative stress, activating autophagy and HIF-1α signaling in diabetic rats.
Authors
- Fabao Gao (ORCID: https://orcid.org/0000-0003-2257-3275)
- Lisha Zhang (ORCID: https://orcid.org/0000-0002-0356-7518)
- Yixuan Wan (ORCID: https://orcid.org/0000-0002-5232-1071)
- Yu Zhang (ORCID: https://orcid.org/0000-0002-6688-5927)
- Lei Wang (ORCID: https://orcid.org/0000-0001-7338-5368)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Archives of Biochemistry and Biophysics
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1016/j.abb.2025.110371
- Citations
- 1
- Primary Topic
- High Altitude and Hypoxia
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Natural Science Foundation of China
- Science and Technology Department of Tibet