Alterbrassacids A and B: Two Novel Fusicoccane Diterpenoids with Protective Activity Against H2O2-Induced Cardiomyocyte Injury from the Fungus Alternaria brassicicola
Abstract Alterbrassacids A and B, two novel fusicoccane diterpenoids featuring a 5/7/6-fused ring system, along with a known structurally related compound were isolated from fungus Alternaria brassicicola. Their structures, including their absolute configurations, were determined by employing a wide range of spectroscopic analyses, DP4+ probability analyses, and ECD calculations. Preliminary studies showed that alterbrassacid A effectively protected cardiomyocyte H9C2 cells from H2O2-induced lactate dehydrogenase leakage. Furthermore, alterbrassacid A exhibited a significant protective effect on mitochondria by reducing the overproduction of reactive oxygen species and enhancing the mitochondrial membrane potential, highlighting it as a promising cardioprotectant.
Authors
- Zhengxi Hu (ORCID: https://orcid.org/0000-0002-1247-5615)
- Jieru Guo (ORCID: https://orcid.org/0000-0001-9129-7679)
- Shenglan Yang (ORCID: https://orcid.org/0000-0001-8307-3712)
- Rui Jiang (ORCID: https://orcid.org/0000-0002-3866-5388)
- Yonghui Zhang (ORCID: https://orcid.org/0000-0002-7222-2142)
- Xiaoqi Jin (ORCID: https://orcid.org/0000-0002-6185-5817)
- Jiangchun Wei
- Weiguang Sun
- Jiayi Guo (ORCID: https://orcid.org/0000-0003-1417-7395)
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Synlett
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1055/s-0043-1775448
- Citations
- 1
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Natural Science Foundation of China
- National Program for Support of Top-notch Young Professionals