Effect of early enteral nutrition on postoperative outcomes in pancreatic cancer patients with diabetes.

This study aimed to evaluate the impact of early enteral nutri-tion support in pancreatic cancer patients with diabetes mellitus following to-tal pancreatectomy. Ninety-six patients were randomly divided into control and research groups, each with 48 patients. Both groups received parenteral nutri-tion, while the research group received additional enteral nutrition within the first 48 hours post-surgery. Results showed that the research group experienced faster recovery of bowel sounds, earlier first defecation, and shorter gastric tube retention times compared to the control group (p<0.05). Postoperative gastrointestinal function, immune function, and nutritional status were signifi-cantly better in the research group, with higher levels of gastrin, motilin, im-munoglobulins G, A, and M, CD4/CD8 ratio, albumin, prealbumin, and trans-ferrin (p<0.05). Furthermore, the research group had better blood glucose control from 48 hours to seven days post-surgery (p<0.05). The above results demonstrated a promoting impact of early nutrition support on postoperative physical functioning recovery of pancreatic cancer patients with diabetes melli-tus. In conclusion, early enteral nutrition support in pancreatic cancer patients with diabetes mellitus significantly improved nutritional status, postoperative gastrointestinal recovery, gastrointestinal and immune function, and blood glu-cose control, leading to a better overall prognosis.