Urinary Biomarkers and Attainment of Cefepime Therapeutic Targets in Critically Ill Children
A large proportion of critically ill children failed to attain target concentrations for empiric treatment of Pseudomonas aeruginosa with cefepime. Urinary biomarkers may be a noninvasive means to identify those at higher risk for increased cefepime clearance and subtherapeutic concentrations.
Authors
- Adam S. Himebauch (ORCID: https://orcid.org/0000-0003-1848-2477)
- Kevin J. Downes (ORCID: https://orcid.org/0000-0001-5015-8146)
- Anna Sharova (ORCID: https://orcid.org/0000-0002-2992-4835)
- Lauren Gianchetti (ORCID: https://orcid.org/0000-0002-9665-6076)
- Athena F. Zuppa (ORCID: https://orcid.org/0000-0002-8662-7474)
- Julie C. Fitzgerald (ORCID: https://orcid.org/0000-0001-9936-9569)
- Victor Amajor (ORCID: https://orcid.org/0009-0007-3235-3643)
Institutions
- Children's Hospital of Philadelphia (US)
- Futures Group (United States) (US)
- Office of Infectious Diseases (US)
- Center for Clinical Research (United States) (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- The Pediatric Infectious Disease Journal
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1097/inf.0000000000004784
- Citations
- 1
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- University of Pennsylvania
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of General Medical Sciences
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Center for Advancing Translational Sciences