Non-targeted metabolomic study in plasma in rats with post-traumatic osteoarthritis model
Taurocholate, indoleacrylic acid, alpha-ketoglutarate, and isocitric acid may serve as biomarkers for PTOA joint injury in rats. Menadione, adenosine 5'-monophosphate, and Arg-Gly-Asp exhibited differential expression between severe and mild PTOA groups in rats, potentially reflecting the injury's severity. Further investigation into these molecules in human tissues is warranted to ascertain their utility as biomarkers for PTOA in humans.
Authors
- Chang-Sheng Liao (ORCID: https://orcid.org/0000-0003-4501-6252)
- Peng-fei Han (ORCID: https://orcid.org/0000-0002-2238-2957)
- Chang-peng Zhang
- Xiyong Li
- Weiwei Wang (ORCID: https://orcid.org/0000-0002-2177-8474)
- Yuan Li (ORCID: https://orcid.org/0000-0001-7582-2824)
Institutions
- Zhejiang Chinese Medical University (CN)
- Changzhi Medical College (CN)
- Wenzhou Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1371/journal.pone.0315708
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00