Serum Soluble Toll-Like Receptor 4 is a Predictive Biomarker for Acute Exacerbation and Prognosis of Idiopathic Pulmonary Fibrosis: A Retrospective Study
High sTLR4 level is associated with an increased incidence of AE-IPF and poor prognosis in patients with IPF. The combination of sTLR4 level and monocyte count might be used to stratify patients with IPF according to the risk for AE via reflecting monocyte activation.
Authors
- Taku Nakashima (ORCID: https://orcid.org/0000-0002-0035-674X)
- Noboru Hattori (ORCID: https://orcid.org/0000-0002-8234-942X)
- Kakuhiro Yamaguchi (ORCID: https://orcid.org/0000-0002-9117-1934)
- Hiroshi Iwamoto (ORCID: https://orcid.org/0000-0003-4922-5334)
- Kiyofumi Shimoji (ORCID: https://orcid.org/0000-0001-5382-4730)
- Shinjiro Sakamoto (ORCID: https://orcid.org/0009-0009-3543-0813)
- Shinichiro Ohshimo (ORCID: https://orcid.org/0000-0003-1119-3322)
- Takeshi Masuda (ORCID: https://orcid.org/0000-0003-3557-0049)
- Yasushi Horimasu (ORCID: https://orcid.org/0000-0002-3390-8491)
- Hironobu Hamada (ORCID: https://orcid.org/0000-0002-7979-0708)
- Erika Kitadai
Institutions
- Hiroshima University (JP)
Publication Details
- Journal
- Lung
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1007/s00408-025-00800-y
- Citations
- 1
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Hiroshima University