MAP4K4 aggravates microvascular anomalies in diabetic retinopathy in a YTHDF2-dependent manner
Our study highlights the critical role of MAP4K4 in EC dysfunction and diabetic retinal microangiopathy, providing new insights into its molecular pathogenesis. Targeting MAP4K4, particularly through modulation of the YTHDF2/MAP4K4/NF-κB axis, may provide a novel therapeutic strategy for diabetic retinopathy.
Authors
- Wen-jian CHEN
- Qian Yang (ORCID: https://orcid.org/0000-0001-5906-6221)
- Yanjun Wen
- Ran Zhang (ORCID: https://orcid.org/0000-0001-8081-2460)
- Qing Chang (ORCID: https://orcid.org/0000-0003-3733-8980)
- Peng‐Peng Zhu (ORCID: https://orcid.org/0000-0002-5698-1042)
- Xin Huang (ORCID: https://orcid.org/0000-0001-7988-3202)
Institutions
- Fudan University (CN)
- Eye & ENT Hospital of Fudan University (CN)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1007/s00125-025-06398-3
- Citations
- 3
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.12
Funders
- Shanghai Science and Technology Development Foundation
- National Natural Science Foundation of China
- Shanghai Hospital Development Center