Malondialdehyde (MDA) and 8-hydroxy-2’-deoxyguanosine (8-OHdG) levels in canine serum: establishing reference intervals and influencing factors
This is the first study to establish serum RI for MDA and 8-OHdG in a large and diverse canine population. Additionally, the multivariate regression models identified relevant haematological and biochemical, but not biological factors that should be considered when interpreting the results. These findings could significantly enhance the application of MDA and 8-OHdG as biomarkers in clinical settings, and promote further exploration of their value in canine diseases.
Authors
- Lucía de Juan
- Sara Cáceres (ORCID: https://orcid.org/0000-0001-6947-2127)
- Guadalupe Miró (ORCID: https://orcid.org/0000-0003-0981-2470)
- Fátima Cruz‐López (ORCID: https://orcid.org/0000-0002-1142-3944)
- Juliana Sarquis (ORCID: https://orcid.org/0000-0002-6967-6733)
- Juan Carlos Illera del Portal
- Blanca Perez-Montero (ORCID: https://orcid.org/0000-0002-9041-0470)
- Maria Luisa Fermin-Rodriguez
- M. Portero‐Fuentes
Institutions
- Universidad Complutense de Madrid (ES)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2025-03-12
- DOI
- https://doi.org/10.1186/s12917-025-04614-1
- Citations
- 4
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 3.22